Allogenic bone transplantation versus autologous bone grafting for repair of limb comminuted fractures: bony union and bone activity

doi:10.3969/j.issn.2095-4344.2015.08.011

Abstract

Abstract:

BACKGROUND: Bone grafting is a commonly used method for treatment of limb comminuted fractures, including allogenic bone transplantation and autologous bone grafting, both of which have their own merit and demerit.

OBJECTIVE: To explore the clinical effect of bone allograft and autograft in repairing limb comminuted fractures from the aspects of bone healing and bone activity.

METHODS: A retrospective analysis was performed on the clinical data of 49 cases of limb fractures which were divided into control group (allogenic bone transplantation) and observation group (autologous bone grafting) according to treatment methods. Clinical healing time, bony union time, and bone specific alkaline phosphatase activity were observed and compared between the two groups.

RESULTS AND CONCLUSION: The bone healing time and bony union time were (5.8±1.2) weeks and (5.8±1.5) months, respectively, in the observation group and (6.1±1.3) weeks and (6.1±0.8) months, respectively, in the control group, but there was no significant difference between the two groups (P > 0.05). The bone specific alkaline phosphatase activities were (10.45±1.53) μg/L in the observation group and (13.58±1.69) μg/L in the control group, and there was a marked difference between the two groups (P < 0.05). These findings indicate that both of allogenic bone transplantation and autologous bone grafting can achieve good results in the repair of limb comminuted fractures, but the autologous bone grafting has certain advantages in the promotion of bone healing ability.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

全文链接：

Key words: Bone Transplantation, Fracture Healing, Fractures, Comminuted, Alkaline Phosphatase

CLC Number:

R318

Du Hui, Fu Qin. Allogenic bone transplantation versus autologous bone grafting for repair of limb comminuted fractures: bony union and bone activity [J]. Chinese Journal of Tissue Engineering Research, 2015, 19(8): 1206-1210.

Figures/Tables 2

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